Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay
The ERA study examined whether variation in DAT1 and DRD4 genes moderated associations between early institutional deprivation and attention-deficit/hyperactivity symptoms at ages six, 11 and 15. DAT1 variation moderated the association from early adolescence into mid-adolescence; the equivalent DRD4 interaction was not found.
Limitations: This observational candidate-gene analysis does not support individual prediction or genetic diagnosis. The abstract does not specify all symptom informants. Findings concern extreme institutional deprivation and share participants with other ERA papers, including the associated doctoral thesis.
- Research type
- Longitudinal study
- Source reviewed
- Abstract
- Peer reviewed
- Yes
- Age group
- Children / Adolescents
Study context and review
Age group as recorded: Children / adolescents
Adoption context: Mixed adoption pathways
Programme: English and Romanian Adoptees Study
Institutional context: No relationship identified in the material checked
No adoption-sector organisational relationship identified from metadata reviewed. Funding and conflicts were not comprehensively audited; this is not confirmation of institutional independence.
Bibliographic screening. Bibliographic relationships are not a bias or safety rating.
Topics: ADHD, genetics, institutional deprivation, longitudinal research
Review scope: Source checked: Abstract. This does not imply full-text or independent human verification.
Country as recorded: United Kingdom
- Funding
- Not yet checked for this entry
- Commissioner
- Not yet checked for this entry
- Funder role
- Not yet checked for this entry
- Declared conflicts
- Not yet checked for this entry
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not yet checked for this entry
Entry: study_ff1ca1de421d4cdd