Genetic and Nongenetic Components of Stroke Family History: A Population Study of Adopted and Nonadopted Individuals
Researchers analysed UK Biobank genetic data and family histories in 495,640 participants, including 5,747 adoptees, with about 13 years of follow-up for stroke and myocardial infarction. Stroke family history was associated with incident stroke among adoptees, while heart-disease family history was not associated with myocardial infarction in adoptees. Polygenic scores showed disease-specific associations in both adopted and non-adopted groups.
Limitations: Observational family-history associations do not establish individual genetic or environmental causes. Adoption circumstances and the interpretation of reported family relationships require caution. UK Biobank volunteers are not representative of every adoptee; this is adult health research rather than direct accounts of adoption. Publications share UK Biobank participants.
- Research type
- Secondary cohort analysis
- Source reviewed
- Abstract
- Peer reviewed
- Yes
- Age group
- Adults / Older adults
Study context and review
Age group as recorded: Adults / older adults
Adoption context: Mixed adoption pathways
Programme: UK Biobank
Institutional context: No relationship identified in the material checked
No adoption-sector organisational relationship identified from metadata reviewed. Funding and conflicts were not comprehensively audited; this is not confirmation of institutional independence.
Bibliographic screening. Bibliographic relationships are not a bias or safety rating.
Topics: genetics, longitudinal research, medical history, physical health
Review scope: Source checked: Abstract. This does not imply full-text or independent human verification.
Country as recorded: United Kingdom
- Funding
- Not yet checked for this entry
- Commissioner
- Not yet checked for this entry
- Funder role
- Not yet checked for this entry
- Declared conflicts
- Not yet checked for this entry
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not yet checked for this entry
Entry: study_8a66cbc42f633aa1