Epigenomic Approaches to Neuropsychiatric Health and Disease Across the Life-course
The adoptee component examined epigenetic associations with early institutional deprivation in Romanian adoptees. A DNA methylation region linked to CYP2E1 was associated with deprivation and socio-cognitive abilities. Other thesis components examined twins and neurodegenerative disease and are not adoptee findings.
Limitations: The thesis combines several populations and topics; its ageing-brain findings must not be attributed to adoptees. Biological associations are not proof of causation or a clinical test for adoption-related difficulties. The ERA component overlaps with published methylation research already in this database.
- Research type
- Doctoral thesis
- Source reviewed
- Abstract
- Peer reviewed
- No
- Age group
- Mixed
Study context and review
Age group as recorded: Mixed
Adoption context: Mixed adoption pathways
Programme: English and Romanian Adoptees Study
Institutional context: No relationship identified in the material checked
No adoption-sector organisational relationship identified from metadata reviewed. Funding and conflicts were not comprehensively audited; this is not confirmation of institutional independence.
Bibliographic screening. Bibliographic relationships are not a bias or safety rating.
Topics: genetics, institutional deprivation, research methodology
Review scope: Source checked: Abstract. This does not imply full-text or independent human verification.
Country as recorded: United Kingdom
- Funding
- Not yet checked for this entry
- Commissioner
- Not yet checked for this entry
- Funder role
- Not yet checked for this entry
- Declared conflicts
- Not yet checked for this entry
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not yet checked for this entry
Entry: study_7e2e612e5708a48e