Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants
Researchers analysed 294 exposures against mental-health outcomes in 157,298 UK Biobank questionnaire participants, using split-sample screening and multivariable models. Reported childhood adoption was associated with having ever self-harmed in the multivariable analysis. This was one association within a wider study of environmental and personal characteristics.
Limitations: Self-reported historical adoption and self-harm are observational measures; association does not establish that adoption caused self-harm. UK Biobank participants and mental-health questionnaire respondents are selected adult samples. Many exposures were screened, and this is not a dedicated adoptee interview study. It does not measure adoptee suicide rates.
- Research type
- Exposome-wide association study
- Source reviewed
- Full text
- Peer reviewed
- Yes
- Age group
- Adults
Study context and review
Age group as recorded: Adults
Adoption context: Mixed adoption pathways
Programme: UK Biobank
Institutional context: No relationship identified in the material checked
No adoption-sector organisational relationship identified from metadata reviewed. Funding and conflicts were not comprehensively audited; this is not confirmation of institutional independence.
Bibliographic screening. Bibliographic relationships are not a bias or safety rating.
Topics: administrative data, adoptee voice, adult outcomes, mental health, Self-harm
Review scope: Source checked: Full text. This does not imply full-text or independent human verification.
Country as recorded: United Kingdom
- Funding
- Not yet checked for this entry
- Commissioner
- Not yet checked for this entry
- Funder role
- Not yet checked for this entry
- Declared conflicts
- Not yet checked for this entry
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not yet checked for this entry
Entry: study_7282c92fc4c820cb