No Evidence for Passive Gene-Environment Correlation or the Influence of Genetic Risk for Psychiatric Disorders on Adult Body Composition via the Adoption Design
The study compared body-composition measures in 6,165 adoptees and 6,165 matched non-adopted UK Biobank participants. Researchers tested whether genetic heritability or psychiatric-disorder polygenic associations differed between groups. They found no evidence for the proposed passive gene–environment correlation or for differences in psychiatric genetic-risk effects on adult body composition in this design.
Limitations: A null result in these measures and this adult sample does not establish absence of all gene–environment processes. Childhood measures and detailed adoption circumstances were unavailable in the reviewed abstract. Selection and ancestry restrictions limit generalisation; cohort participants overlap across publications.
- Research type
- Secondary cohort analysis
- Source reviewed
- Abstract
- Peer reviewed
- Yes
- Age group
- Adults / Older adults
Study context and review
Age group as recorded: Adults / older adults
Adoption context: Mixed adoption pathways
Programme: UK Biobank
Institutional context: No relationship identified in the material checked
No adoption-sector organisational relationship identified from metadata reviewed. Funding and conflicts were not comprehensively audited; this is not confirmation of institutional independence.
Bibliographic screening. Bibliographic relationships are not a bias or safety rating.
Topics: genetics, physical health, research methodology
Review scope: Source checked: Abstract. This does not imply full-text or independent human verification.
Country as recorded: United Kingdom
- Funding
- Not yet checked for this entry
- Commissioner
- Not yet checked for this entry
- Funder role
- Not yet checked for this entry
- Declared conflicts
- Not yet checked for this entry
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not yet checked for this entry
Entry: study_41f09db978835e84