Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study
A follow-up of three US cohorts used prenatal records to establish exposure and questionnaires to identify diagnoses. Prenatal DES exposure was associated with undescended testes, epididymal cysts and testicular inflammation or infection, especially with exposure early in pregnancy. Several other urogenital conditions showed no association.
Why it matters to adoptees: The possible health relevance of missing prenatal medication history also extends to male adoptees.
Limitations: Outcomes were reported by participants. Not an adoptee sample; findings concern prenatal exposure. Does not demonstrate infertility in all exposed men or establish effects of treatment after a previous birth. Related NCI publications may share participants.
- Research type
- Observational cohort study
- Source reviewed
- Abstract
- Peer reviewed
- Yes
- Age group
- Adults
Study context and review
Age group as recorded: Adults
Adoption context: Medical evidence relevant to adoptees; not an adoptee sample
Programme: NCI DES Follow-up Study
Institutional context: Government / government-commissioned research
US National Cancer Institute collaborative research programme. Public research body; funding/commissioning details require study-specific review.
Scoped bibliographic and source review. Bibliographic relationships are not a bias or safety rating.
Topics: adoptee-relevant medical evidence, DES, diethylstilbestrol, male health, medical history, physical health, Prenatal exposure
Review scope: PubMed abstract and bibliographic record.
Country as recorded: United States
- Funding
- Not yet checked
- Commissioner
- Not yet checked
- Funder role
- Not yet checked
- Declared conflicts
- Not yet checked
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not established in material reviewed
Entry: study_2ff436b4952dcaf2