Birth Outcomes in DES Children and Grandchildren: A Multigenerational National Cohort Study on Informative Families
Researchers selected 74 women with children born before, during and after DES treatment and eligible grandchildren. Premature births were reported in 2.7% of pre-treatment children, 14.9% of children exposed during pregnancy and 10.8% of children born after treatment. The design examined pregnancy duration and birthweight across generations.
Why it matters to adoptees: Closest of this batch to the question about later children born after maternal DES treatment. Supports a research question, not an established risk estimate for later-born adoptees.
Limitations: Small, selected sample recruited through a patient-family association with restrictive eligibility criteria. Birth order and maternal age differ between exposure groups; within-family comparisons do not remove all confounding. Does not establish that second children generally have increased risk, nor specifically test DES used for milk suppression after a previous adoption. Full text could not be comprehensively retrieved.
- Research type
- Observational cohort study
- Source reviewed
- Abstract
- Peer reviewed
- Yes
- Age group
- Adults / Offspring across generations
Study context and review
Age group as recorded: Adults; offspring across generations
Adoption context: Medical evidence relevant to adoptees; not an adoptee sample
Programme: HHORAGES-France DES informative families
Institutional context: Other
University/medical researchers with HHORAGES-France patient-family association recruitment. Association involvement may affect sample selection; no adoption-sector affiliation identified in material checked.
Scoped bibliographic and source review. Bibliographic relationships are not a bias or safety rating.
Topics: adoptee-relevant medical evidence, birthweight, DES, diethylstilbestrol, medical history, multigenerational health, premature birth, subsequent pregnancy
Review scope: Indexed abstract and selected indexed methods/funding passages; no comprehensive full-text review.
Country as recorded: France
- Funding
- Authors state no external research funding; other acknowledgements and individual support not fully reviewed.
- Commissioner
- Not yet checked
- Funder role
- Not yet checked
- Declared conflicts
- Not yet checked
- Recruitment
- Not yet checked for this entry
- Adoptee involvement
- Not established in material reviewed
Entry: study_07073878312fd93c